I-35W & 46th Street station is a Metro Orange Line bus rapid transit station located in Minneapolis, Minnesota. In addition to the BRT service, the station is also served by Metro route 578. The station was constructed as part of the I-35W/Minnesota State Highway 62 Crosstown Commons reconstruction project and opened in 2010. Consisting of two levels, one on East 46th Street, and the other in the median of Interstate 35W, the station was the first of its kind in Minnesota. The station allows for transit routes operating on I-35W to stop for riders without leaving the region's high occupancy toll lane system. The station was designed in anticipation of full bus rapid transit service along I-35W to downtown Minneapolis, a vision that was realized in 2021 with the opening of the Metro Orange Line. The station cost $4.5 million to build.